For an oocyte to be ready for fertilization and growth into an embryo, the best list of genes needs to be turned on. Namekawa suspected this pre-programming on the oocyte genome occurs in several levels — the first a single starting across the time a woman is born. He believed that chromatin remodeling proteins did Significantly of this operate, by shifting spools around.
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“If we know how this chromatin state is established, And exactly how it relates to oocyte good quality, it could sooner or later bring on therapies for some varieties of infertility,” suggests Namekawa.
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Munakata and Namekawa will compare mice with typical and mutated versions with the chromatin remodeler. Given that the mice develop and experienced, they will observe if the existence or absence of the protein triggers variances in the arrangement of DNA spools in the animals’ oocytes. And they're going to monitor no matter if this, subsequently, alters the sample of gene expression with time.
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This protein may well “build and maintain the chromatin state,” states Namekawa — trying to keep the spools set up as well as oocytes genetically primed as the mouse matures.
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